LIFESTYLE 
8 MIN 
ALMAGEA 
28.01.2026
For health problems such as overweight, obesity (especially in the abdominal area), elevated levels of glucose, insulin, cholesterol and triglycerides in the blood, in addition to drug therapy, we also have natural approaches that supplement standard medicine. In the search for metabolic health, while ensuring balanced blood sugar and reduced desire for food, two natural compounds stand out - white mulberry leaf extract and inositol. These compounds offer a beneficial effect on health, but are they the right solution for everyone? When it comes to nutritional supplements, what is a medicine for someone, is ineffective for another or even poses a health risk.
The condition of prediabetes is a condition in which several blood sugar measurement values deviate from the recommendation, however, the values are not high enough to be diagnosed with type 2 diabetes. Prediabetes increases the risk of developing diabetes, heart disease and stroke, so in this case the doctor will recommend a change in lifestyle that includes a healthy diet, more movement and physical activity, and reducing excess body weight. Among these recommendations, we can also include the intake of dietary supplements for metabolic health, which can help lower blood sugar levels in a natural way. Insulin resistance is generally considered a progressive condition if the underlying causes are not addressed. However, progression is not inevitable and can be slowed, stopped and even reversed with lifestyle changes and, if necessary, medication.And if type 2 diabetes has already been diagnosed, timely treatment can avoid or delay the development of chronic complications (heart disease, nerve, eye and kidney damage, and cognitive impairment) and improve the quality of life of a person with type 2 diabetes.
Alleviating spikes in blood sugar and insulin can help reduce food cravings, promote satiety, and thus help better control food energy intake.
Keeping your blood sugar stable can help reduce food cravings, especially sugar, and help with symptoms like low energy during the day, chronic fatigue, and stress hormone (cortisol) imbalances.
Dietary supplements for metabolic health are not recommended for these population groups because there is no research confirming their safety and effectiveness.
Patients with type 1 diabetes are not recommended to take food supplements with white mulberry leaf extract. Since the natural alkaloid from white mulberry can lower blood sugar levels, if it is combined with insulin there is a risk of hypoglycemia, a dangerously low blood sugar condition.
The mechanism of action of white mulberry leaf extract involves blocking the absorption of carbohydrates, so in the case of a diet with a minimal amount of carbohydrates, this dietary supplement becomes ineffective or unnecessary.
Similar to patients on insulin therapy, people on blood sugar-lowering drug therapy must be careful if they take additional nutritional supplements for metabolic health. White mulberry leaf extract lowers the blood sugar level, so hypoglycemia could occur with medication, especially in the case of therapy with sulfonylurea derivatives.
Međutim, valja naglasiti kako unatoč modernim lijekovima koji se rabe u liječenju šećerne bolesti, velik dio oboljelih i dalje ne postiže zadovoljavajuću regulaciju glikemije, a ni ostalih metaboličkih parametara ključnih u postizanju dobre kontrole bolesti i smanjivanju kroničnih komplikacija. Također, u liječenju šećerne bolesti tipa 2 zlatni standard je individualni pristup, stoga u odabiru terapije kod nekih oboljelih unos dodataka prehrani s ekstraktom bijelog duda je opravdano i korisno. Valja napomenuti da se odluka o unosu dodataka prehrani u ovom slučaju does not perform independently, but certainly in cooperation and under the supervision of a doctor.
In a study published in 2011, scientists tested the effect of white mulberry leaf extract (in the form of sweetened jelly) on glucose and insulin levels after a meal in patients with type 2 diabetes. They compared the results with those obtained after taking a placebo. 10 subjects suffering from type 2 diabetes took part in the research, of which 5 subjects were not treated with drugs, while 5 were treated with sulfonylurea derivatives. Also, 10 healthy subjects participated in the research.
This study clearly demonstrated that consumption of white mulberry leaf extract significantly reduced the postprandial rise in glucose and insulin in type 2 diabetics, regardless of whether they were on medication. A preparation with white mulberry extract also reduced the postprandial rise in glucose and insulin in healthy subjects. In addition, the preparation with white mulberry extract caused an increased excretion of hydrogen in the exhaled air, which indicates a lower energy value and probably a prebiotic effect. Excretion of hydrogen in exhaled air shows that white mulberry extract prevents the decomposition of sucrose from the preparation, so it is transferred to the large intestine where it is fermented by intestinal bacteria. In this way, the mechanism by which white mulberry extract reduces the increase in glucose and insulin in the blood can be clearly explained.
In addition to white mulberry leaf extract, inositol was also investigated. Inositol is used as a dietary supplement in various diseases such as PCOS, metabolic syndrome and diabetes in pregnancy. Two types of inositol, myo-inositol and D-chiro-inositol, can mimic the action of insulin in people with insulin resistance. Since type 2 diabetes is most often associated with insulin resistance, the researchers wanted to see if inositol could help in this case as well.
In a small study, people with type 2 diabetes (average age 61 years) took a combination of myo-inositol and D-chiro-inositol twice daily for three months, in addition to their regular therapy. After this period, their fasting sugar levels and HbA1c (an indicator of average blood sugar levels) decreased significantly, and there were no side effects, indicating that myo- and D-chiro-inositol supplementation may be a safe and effective way to improve blood sugar regulation in type 2 diabetes.
Almagea® METABOSS+ je dodatak prehrani koji doprinosi metaboličkom zdravlju i održavanju normalne razine šećera u krvi, a sadrži djelotvorne prirodne spojeve: patentirani sastojak Reducose® iz ekstrakta lista bijelog duda te mio- i D-kiro- inozitol u idealnom omjeru 40:1. Metaboličke procese olakšava i prisutnost vitamina B6, B9 and B12 te aktivnog folata (Quatrefolic®) i kroma.
It is recommended to introduce Metaboss+ in combination with an adapted diet and exercise, as well as with the implementation of relaxation techniques and sufficient sleep. The application involves taking one bag per day dissolved in a glass of water, immediately before the meal that is the richest in carbohydrates, for easier maintenance of normal blood sugar levels and better metabolic health.
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