Supportive form of therapy in psoriasis

Psorijaza je učestala kronična upalna bolest kože koja obično slijedi tijek povlačenja i pogoršanja. Najčešća vrsta psorijaze odlikuje se mrljama s izrazitim granicama koje mogu biti ružičaste ili sive boje sa srebrnkastom ljuskavom kožom. Ove mrlje mogu uzrokovati i lokaliziranu hiperpigmentaciju. Simptomi se mogu po prvi put pojaviti u bilo kojoj dobi, međutim, najčešće se pojavljuju u ranim fazama odrasle dobi ili kasnije u životu, tijekom 50-ih do 60-ih godina.

Astaxanthin and the effect on the skin

Several studies have demonstrated the role of astaxanthin in improving appearance. We will single out three studies:

1. 1. A study conducted in Japan involving women in their 40s who took 2 mg of astaxanthin daily for 4 weeks showed that almost every aspect of the health and appearance of the woman's skin improved after just 2 weeks of therapy.The improvement was even more visible after 4 weeks. The effects of astaxanthin included the reduction of wrinkles, better moisture, improved skin tone and elasticity, a smoother surface and less impurities.

1. 1. A Canadian study from 2003, which included women between the ages of 35 and 55 who received astaxanthin in combination with omega-3 fatty acids and marine glycosaminoglycans, showed that said supplementation resulted in an improvement in the health and appearance of the skin in all measured parameters.

1. 1. A European study examined the impact of the intake of 5 mg of astaxanthin along with two other ingredients. The results showed that supplementation results in a reduction in the appearance of wrinkles, a 78% increase in the density of the dermis, and visible positive changes in the overall appearance of the skin.

When taking astaxanthin, it would be good to pay attention to whether the preparation contains natural or synthetic astaxanthin. Namely, it is synthetically obtained from petrochemicals and has a 20 times weaker effect than the natural one.

Source: Journal of Dermatological Science 2010 May;58(2):136-42.

How does astaxanthin affect oxidative stress?

Astaksantin, pigment iz porodice karotenoida, uglavnom se nalazi u algama – Haematococcus pluvialis – kojima se hrane ribe poput lososa. Njegovo antioksidacijsko djelovanje je i do 500 puta jače od onog koje ostvaruje vitamin E.

Daily supplementation with astaxanthin can protect DNA from oxidative damage and raise the function of the immune system to a higher level, claims a new American study.

Research conducted on 42 women with an average age of 21, which lasted 8 weeks, showed that the consumption of a few milligrams of astaxanthin has a significant effect on the body's defense mechanisms. Several indicators were observed: 8-OHdG (8 hydroxy-2-deoxyguanosine), CRP (C reactive protein), NK cells and T and B lymphocytes. 8-OhdG, a direct indicator of DNA damage, in the group that received 2 mg per day dropped by 32% and at 8 mg per day by as much as 43%. CRP, an indicator of inflammation, was significantly reduced, and the activity of T and B lymphocytes and NK cells was significantly increased.

Izvor: Park JS, Chyun JH, Kim YK, Line LL, Chew BP. (2010) Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr. Metab. Mar 5;7:18.

Q₁₀, vitamin E and selenium for psoriasis

Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the population, greatly reduces the quality of life and usually lasts a lifetime, and 10-30% of patients develop psoriatic arthritis. The clinical results of conventional therapy of more severe forms of psoriasis are not satisfactory and there is a problem of toxicity of the drugs used, so patients often use herbal preparations, nutritional supplements (eg omega-3 fatty acids and β-carotene) and specific diets.

A new study on a group of 58 patients with severe forms of psoriasis shows for the first time that a combination of antioxidants and conventional therapy improves the condition and simultaneously reduces the level of oxidative stress.The subjects were given coenzyme Q for a month₁₀ (50 mg/d), vitamin E (50 mg/d) i selen (48 µg/d).

Taking nutrients in the form of dietary supplements has significantly reduced markers of oxidative stress and is emerging as a useful additional, supportive form of therapy in people with a severe form of psoriasis.

Selenium in skin protection

Selenium is a trace element that affects the immune system. Namely, according to the study, lower selenium is associated with a 60% lower risk of skin cancer. The study involved 485 adult subjects who were divided into three groups with regard to the concentration of carotenoids, vitamin E and selenium in the serum.

The risk of skin cancer was monitored over a period of 8 years.Although no influence of carotenoid and vitamin E levels on the incidence of cancer was observed, the concentration of selenium in the serum had an inversely proportional influence on the occurrence of skin cancer. In particular, compared to subjects who had the lowest level of selenium (0.4-1.0 µmol/L), those with the highest level of selenium in the serum (1.3-2.8 µmol/L) were even 60% less likely to suffer from skin cancer.

Source: Van der Pols JC, Heinen MM, Hughes MC, Ibiebele TI, Marks GC, Green AC. (2009) Serum antioxidants and skin cancer risk: an 8-year community-based follow-up study. Cancer Epidemiol. Biomarkers Prev. Apr;18(4):1167-73.

Selenium is an essential element found in the body in small amounts. However, it has many important tasks in the body. Selenium is an integral part of the enzyme called glutathione peroxidase and as such contributes to the protection of cells from oxidative stress.

Nadalje, pridonosi normalnoj funkciji imunološkog sustava pa nedostatak selena slabi otpornost na infekcije kao rezultat smanjene funkcije bijelih krvnih zrnaca i prsne žlijezde. Također pridonosi normalnom radu štitne žlijezde budući da pomaže regulaciju proizvodnje hormona trijodtironina i trijodtiroksina.

Another important property of selenium is that it contributes to the maintenance of normal hair and nails, so, for example, an insufficient intake of selenium can be manifested by loss of hair color or a change in the color of nails.

Author: Vitaminoteka nutritionist team