L-tyrosine: the key link between the thyroid and stress

Kad smo pod stresom, naše tijelo troši više nutrijenata nego inače. Među njima posebno se ističe L-tirozin, aminokiselina koja pomaže štitnjači i umu da ostanu u ravnoteži. Jeste li znali da je L-tirozin ključna gradivna jedinica hormona štitnjače? U kombinaciji s jodom, štitnjača ga koristi za sintezu tiroksina (T4), hormona koji sadrži četiri atoma joda vezana na molekulu tirozina. Iz njega potom nastaje trijodtironin (T3), aktivniji oblik hormona koji nastaje posebnim biosintetskim procesom unutar same žlijezde. Kada u organizmu nema dovoljno tirozina, štitnjača ne može stvarati optimalne količine ovih hormona, što može dovesti do slowed down work of the gland, odnosno hypothyroidism.

The link between stress and the thyroid that affects the entire organism

It is known that both acute and chronic stress can negatively affect thyroid function. Thyroid hormones participate in the regulation of metabolism and the body's sensitivity to cortisol, the main stress hormone. When thyroid hormone levels drop, the hypothalamus-pituitary-adrenal axis (HPA axis), which controls cortisol secretion, can be disrupted. This is why thyroid health and stress levels are inextricably linked, any imbalance in one system affects the other.

Stress is modern enemy number 1

In today's age, there are few people who do not somehow come into contact with stress, at work, at home or in an attempt to balance both. Almost two-thirds of Croats, or 60%, feel a medium level of stress, and even 30% feel a high level of stress. In general, we say that today stress is a growing public health problem that has a negative impact on the quality of life, and is associated with diseases of the heart and blood vessels, malignant diseases, digestive disorders and diseases, and obesity. Continuous exposure to stressful situations significantly weakens the immune system and makes us susceptible to various infections and diseases. This is precisely why it is important to know how to control the appearance of stress and reduce its negative consequences that arise on a physiological and emotional level, and are manifested by feelings of anger, fear, depression, anxiety, sleepiness or insomnia.

How stress changes our immunity

When we are exposed to stress, numerous chemicals are secreted in the body, including stress hormones, adrenaline and cortisol, which stimulate the increased work of the immune system in order to defend against disease. However, when the stressful period passes, the secretion of stress hormones is significantly reduced, which is a sign to the immune system that the danger has passed and it relaxes, making us less resistant to diseases. At the same time, remaining prostaglandins, substances released in response to stress, can cause inflammatory processes in the body. Therefore, the period after intense stress is "critical" for the manifestation of certain minor, but also more serious health problems.

Nutrition as an ally in the fight against stress

Prehrana i dodaci prehrani moćni su čimbenici koji mogu olakšati ili onemogućiti ispoljavanje simptoma stresa u organizmu. Pravilno izbalansirana i redovita prehrana sama po sebi pruža značajnu zaštitu osobama izloženim stresnim situacijama. U tim razdobljima organizam se iscrpljuje intenzivnije nego inače zbog pojačane stanične aktivnosti te se istovremeno javlja i pojačana potreba za nutrijentima. Poseban značaj za homeostazu organizma imaju proteini i određene aminokiseline, antioksidansi, vitamini B skupine, esencijalne masne kiseline, željezo, selen, kalcij i magnezij, a dodatnu korist pružaju i odabrane ljekovite biljke s adapdogenim djelovanjem. Posebno je interesantna uloga tirozina koja intrigira već godinama, a u posljednje vrijeme intervencijske studije ukazuju na benefit of tyrosine supplementation na kognitivne funkcije tijekom stresnih razdoblja.

The role of proteins and amino acids in maintaining the balance of the organism

Chronically elevated cortisol increases catabolism (protein breakdown) and stimulates the production of catecholamines through the sympathetic system, which increases the metabolic need for tyrosine. The increased need for proteins is partly conditioned by the increased work of the adrenal gland, so during stress hormones, which regulate the conversion of proteins into carbohydrates, are secreted at a higher intensity than usual, which leads to an accelerated breakdown of proteins. A diet low in protein can also result in a weakening of the immune system and its ability to resist various infections.

From tyrosine to dopamine - the chemistry of good mood and focus

U razdobljima stresa, potrebe tijela za određenim nutrijentima rastu, a među njima posebno za aminokiselinom tirozinom. Ona se u takvim okolnostima smatra conditionally essential, which means that the body cannot always produce enough of it on its own, but sometimes it needs to be additionally ingested with food or nutritional supplements. Tyrosine is crucial because it is the precursor, i.e. the starting material, for the creation of important brain chemicals: catecholamines, dopamine, noradrenaline and adrenaline. These neurotransmitters play a crucial role in the functioning of the brain and the response to stress.

• Dopamine is not only responsible for feelings of satisfaction and motivation; it also helps in coordinating movements, maintaining concentration and controlling impulsiveness.
• Noradrenaline improves alertness, attention and the ability to focus despite stress or distractions.
• Adrenaline, also known as the "fight or flight" hormone, helps the body to quickly adapt to stressful situations.

This is why a sufficient intake of L-tyrosine can help the brain function better under pressure, supporting focus, mental clarity and resistance to stress.

Can tyrosine help with brain fog and exhaustion?

Tyrosine is a direct precursor of dopamine. Dopamine can then be converted into noradrenaline and adrenaline. Supplementation with tyrosine can increase the availability of dopamine, especially in stressful situations or with mental exhaustion. Additional use of L-tyrosine can help preserve working memory, control stress and mood. Changes in the availability of L-tyrosine for the brain, such as occur in a state of stress, can affect the synthesis of dopamine and noradrenaline. Therefore, it is logical that the most important effect of L-tyrosine is the mitigation of cognitive impairment and the so-called "foggy brain", created under the influence of acute stress.

In a study published in 2015, scientists analyzed 10 randomized controlled studies and 4 controlled clinical studies on the use of L-tyrosine. The results showed that there is not enough evidence that tyrosine improves physical performance under stressful conditions, but all studies showed a positive effect on mental (cognitive) functions under stress, which is why the authors gave a mild recommendation in favor of the use of tyrosine in mental stress.

Nutritional support for the thyroid gland in periods of stress

Stress and thyroid hormones are closely related; long-term stress can disrupt hormone balance and weaken thyroid function, while reduced thyroid activity further increases sensitivity to stress and fatigue. That is why, along with a balanced diet and a healthy lifestyle, targeted nutritional support can be of great benefit.

Almagea Thyroideal+ je formulacija posebno osmišljena za optimalnu podršku funkciji štitnjače i bolju otpornost organizma na stres. Sadrži pažljivo odabrane nutrijente koji djeluju sinergijski:

• L-tyrosine, a key amino acid for the synthesis of thyroid hormones, helps create thyroxine (T4) and triiodothyronine (T3) and supports mental clarity and focus during stressful periods.
• Selenium doprinosi normalnoj funkciji štitnjače, osobito u pretvorbi neaktivnog T4 u aktivni T3 oblik.
• Vitamin B₆ pomaže u regulaciji hormonske aktivnosti i sudjeluje u stvaranju neurotransmitera važnih za otpornost na stres.
• Iodine je ključan za normalnu proizvodnju hormona štitnjače i njezino optimalno funkcioniranje.
• Uz njih, B vitamins₁, B₃, B₁₂, vitamin E, folic acid and copper dodatno podržavaju metabolizam energije i antioksidacijsku zaštitu stanica.

Ova kombinacija čini Almagea Thyroideal+ učinkovitim saveznikom zdrave štitnjače, stabilne energije i bolje prilagodbe na svakodnevne izazove.

Literature:

• Attipoe S, Zeno SA, Lee C, Crawford C, Khorsan R, Walter AR, Deuster PA. Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature. Mil Med. 2015 Jul;180(7):754-65.